In a challenge study the efficacy of ECONOR was tested at a dose level of 25ppm (treatment period: 4 days prior + 14 days post challenge).
 
Results: ECONOR effectively prevented spirochaetal colitis with substantial clinical and microbiological improvements.
 

Challenged unmedicated control Challenged medicated ECONOR Improvement (%) No. of pigs 9 9   No. with diarrhoea 1 0 100 No. with gross lesion at necropsy 2 0 100 No. with inflammatory lesions in the colon on histology 6 0 100 No. in which spirochaetes were evident on histology 2 0 100 Average daily gain (g) 480 473 -1.5 Feed conversion efficiency 1.65 1.55 6.1

Ripley et al. 1998

 

The efficacy of ECONOR was evaluated in a challenge study at a dose level of 1.25mg/kg bw (25ppm) (medication period: 2 to 27 days post-exposure).
 
Results: Excellent protection against PCS infection. Reduction of severity of clinical signs by 65% and excretion of B.pilicosi. by 97%. Improvement in daily gain (+30%) and gain/feed (+18%).

Challenged unmedicated control Challenged medicated ECONOR Significance (P<) No. of pigs 35 36   No. with colonisation/excretion B. pilosicoli 32/35 1/36* (-97%) 0.002 No. with diarrhoea 11/35 10/36   Days of diarrhoea 111 31   Diarrhoea score 0.54 0.19 (-65%) 0.047 Average daily gain (kg/day) 0.47 0.61 (+30%) 0.012 Gain/feed 0.57 0.67 (+18%) 0.014

* No. of pigs affected / total no. of pigs

Morgan et al. 2002

One field study was conducted in a farm (SPF herd, free from SD and PPE) in United Kingdom to evaluate the efficacy in the prevention of a naturally- occurring outbreak of Colitis. 
 
ECONOR was given at 1.25mg/kg bw for 28 days.
 
Results: ECONOR was highly effective in the prevention of Colitis. Reduction of the clinical signs resulted in a significant improvement in performance.
 

 
 

Mean faecal score
 

 

Glossop and others (2000)

 
 

Pigs with faecal score > 2 (in %)
 

 

Glossop and others (2000)

 
 

Weight gain, feed conversion and condition score

Placebo ECONOR Average daily gain (g)   Day 0 - 28 365 429* (+17.5%) Mean cumulative general condition score   Day 0 - 28 3.1 1.5* Feed conversion efficiency   Day 0 - 28 2.167 2.026 (+6.5%)

* P < 0.01

Glossop and others 2000