Potent Activity For Effective Control Of The Complex Of Enteric Diseases
COLITIS: Microbiological activity – Brachyspira pilosicoli MICs (mcg/ml)
  Dalziel
UK (1996)
Møller
Denmark (1996)
Kinyon
USA (2002)
  MIC Range
(no. of strains=12)
MIC50 MIC Range
(no. of strains=5)
MIC50 MIC Range
(no. of strains=25)
MIC50
Valnemulin 0.015-0.125 0.018 0.015 0.0156 0.03-2.0 0.06
Lincomycin 0.25-12.5 4.32 0.5-128.0 13.8 4.0->128 32
Tylosin 0.0-200.0 31.6 2.0->128.0 24 <16>512 >512

 
 

  Kessler
Germany (2001)
Merialdi
Italy (2003)
Mars & Ripley
UK (2003)
  MIC Range
(no. of strains=13)
MIC90 MIC Range
(no. of strains=10)
MIC50 MIC Range
(no. of strains=10)
MIC50
Valnemulin 0.063-0.25 0.25 <0.067-2.0 0.25 0.0075-0.25 0.04
Lincomycin nd          
Tylosin nd          

 
 

103 isolates of B. pilosicoli were examined routinely for susceptibility to valnemulin in the period between Feb 2000 and June 2003:

  2000 2001 2002 2003
up to Jul 2003
Number of isolates 21 43 29 10
Susceptilbity to Valnemulin (in %) 95% 100% 100% 100%
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